Using regression analysis, we observed no significant differences in responses to polyIC or LPS between RhD-positive and -negative individuals. Whole blood was stimulated with LPS, polyIC, and the live influenza A virus and the NanoString human immunology panel of 560 genes used to assess donor immune response and to investigate sex-specific effects. We used the rs590787 SNP in the RHD gene to classify the 1000 donors as either RhD-positive or -negative. Here, we used transcriptomic and genomic data from the Milieu Interieur cohort of 1000 healthy individuals to explore the effect of Rhesus status on the immune response.
However, potential mechanisms contributing to these associations have not yet been defined. Reports suggest that RhD-negative individuals are better protected against infectious diseases and have overall better health.
The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections.
